Architecture of an algorithm. Inspired by the deeply intriguing compositions of color, shape, and texture pioneered by world-renowned Mexican architect, Luis Barragán, the image symbolizes the temporal progression of simple, perfect-match computations to characterize genome variation. After detected signatures of variation are locally resolved, and discovered variants are introgressed and qualitatively validated, an undisturbed genomic landscape emerges. Artwork by O’Reilly Science Art. See Palacios-Flores et al. pp. 1631–1641 in this issue.

See completed article http://www.genetics.org/content/genetics/208/4/1631.full.pdf